Regenerative Procedures

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Pioneering treatment to regenerate a damaged jaw joint

Advances in regenerative procedures have transformed the way TMJ disorders can be treated. Instead of traditional methods such as massage, physio, muscle relaxants, steroids or invasive surgery, regenerative treatments offer the potential to tackle the root cause of your jaw joint disorder to provide an effective solution.

Why should I have a regenerative procedure?

Regenerative procedures for TMJ disorder work by regenerating the cell tissue in the jaw joint, reducing pain and inflammation. They harness the body’s natural ability for self-repair by re-implanting growth-promoting cells taken from elsewhere in the patient’s body to stimulate healing in the jaw joint.

Regenerative procedures can also be used to:

  • Increase the mobility of your jaw
  • Avoid the need for a jaw joint replacement in some cases
  • Treat a post-radiotherapy jaw
  • Prevent jaw necrosis during an extraction
  • Provide an effective solution for arthritis in the jaw joint

Which regenerative treatments do you use?

At the London TMJ Clinic, we are proud to pioneer regenerative treatments, using these advanced techniques to help our patients achieve the best possible results.

Activated Mesenchymal Pericyte Plasma (AMPP®) injections contain a combination of fat and blood cells and are administered into your jaw joint. Fat tissue is taken from your thigh or stomach before the regenerative cells are separated and mixed with platelets from your blood.

Platelet Rich Plasma (PRP) involves extracting platelets from a sample of your own blood and re-injecting these into the damaged jaw joint to encourage cell repair and regeneration.

Bone Marrow Aspirate Concentrate (BMAC) is a minimally invasive procedure that uses stem cells harvested from your bone marrow to promote healing in your damaged jaw. The treatment accelerates the body’s natural ability to repair and regenerate itself.

Expert surgical treatment from experienced specialists

What does the procedure involve?

If you are a suitable candidate for a regenerative procedure to help your TMJ disorder, we will discuss the procedure with you in detail, helping you understand the process and giving you a chance to ask any questions. Each procedure is slightly different, as detailed below:

Activated Mesenchymal Pericyte Plasma injections (AMPP®)

To begin your treatment, a small amount of fat is taken from your stomach or thigh in a minimally invasive procedure, using local anaesthetic to reduce any discomfort.

The Lipogems® system is used to separate the regenerative cells from your fat tissue, removing any toxins or inflammatory elements while keeping the natural beneficial properties. The fat cells are also resized to best facilitate healing in the treatment site.

For the PRP part of this procedure, a small sample of your blood is taken from your arm and placed in a centrifuge to separate the platelets.

The fat cells and PRP are successfully combined and the AMPP® injection is administered into your jaw, using ultrasound to accurately guide it. The whole process takes around an hour and no lengthy recovery time is needed.

Platelet Rich Plasma (PRP)

Initially, a small blood sample is taken from a vein in your arm. This is then spun in a centrifuge to separate the PRP from the rest of your blood.

We prepare your jaw for treatment and inject the PRP directly into it using a fine needle. The solution will then spread to all parts of the joint to begin the regeneration process.

PRP treatment takes around 20 minutes in total, and you can return to your normal routines immediately after the procedure. To see the maximum benefits and improvements to your TMJ disorder, a course of three injections is recommended.

Bone Marrow Aspirate Concentrate (BMAC)

While you are under local anaesthetic to minimise your discomfort, bone marrow, the spongy tissue in the middle of bones, is taken from your pelvic bone using a needle and syringe. The bone marrow is then separated into its component parts using a centrifuge.

The plasma, which carries essential proteins, is reduced to a General Fluid Concentrate (GMC). The bone marrow contains mesenchymal stem cells (BMSC) and is turned into the Bone Marrow Aspirate Concentrate (BMAC).

The GMC and BMAC are given as separate injections, accurately administered into your damaged jaw joint using local anaesthetic. The procedure is minimally invasive and doesn’t need a lengthy recovery time, reducing any risk factors.

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Frequently Asked Questions
Why are regenerative procedures used?

Regenerative procedures for TMJ disorders use products taken from the patient’s own body, meaning they are entirely compatible with you. The stimulation of regenerative cells creates a healing response, limiting downtime after the procedure and reducing the risk of any side effects. The minimally invasive procedures don’t require any major incisions and are completely safe and trusted.

Are regenerative procedures painful?

We use local anaesthetic during all regenerative procedures, to make sure you remain comfortable and to minimise any pain. If you are concerned about pain, we are happy to discuss this in more detail with you, including the possibility of using sedation if necessary.

What are the risks?

The risk factors for AMPP®, PRP and BMAC for the jaw are low, as the fat, platelets and bone marrow are taken from your own body. The minimally invasive nature of the procedures, with no major incisions or lengthy recovery times, further reduces the risks.

Are regenerative procedures new?

Innovative regenerative procedures have already been used by orthopaedic surgeons as an alternative to invasive surgery or steroid injections to promote healing in the major joints of the body, such as the hip, knee and shoulder. As an Oral & Maxillofacial Surgeon, Luke Cascarini has pioneered the application of these regenerative treatments for TMJ disorders in partnership with The Regenerative Clinic.

Getting in touch

If you would like to discuss treatment, book a consultation or just have a general enquiry, please get in touch.

Referrals from GDPs, GPs and consultants are welcome. Please use this form if you wish to discuss a case prior to referral.

We aim to reply to enquiries within 24 hours.

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